Innovative Science in Virology, Oncology, and Neurology
Allogeneic CD8+ T cell therapies from a single donor to treat thousands for the first time
ExacTcell focuses on the selection and expansion of naturally occurring, genetically unmodified CD8+ CTLs to target multiple, distinct, previously identified antigens present only on infected or malignant cells and to kill those cells.
We believe that by relying on CD8+ CTLs, ExacTcell has the potential to produce an entirely new class of drugs that could present numerous benefits over competitive platforms. In contrast to other approaches, the ExacTcell platform enables a single, specific HLA molecule to be targeted in a clinical product and the specific target peptides to be known with certainty and precision.
CD8+ Cytotoxic T-Lymphocytes
We believe that to date, these cells have not been harnessed to their full potential for clinical application and that our proprietary approach allows T cell products to be generated with a much higher CD8+ content and better-defined target specificity than existing commercially available approaches.
CD8+ Cytotoxic T lymphocytes identify and kill by recognizing antigenic peptides on the surface of the infected or malignant cells.
Highly Efficient Ratio of Doses per Cell Donor
Tevogen’s commercial scale ready first generation manufacturing process already yields a highly efficient ratio of doses per cell donor. The second generation, Tevogen’s proprietary TCR-T process, is expected to dramatically increase the number of doses.
Highly Purified, Target-Specific Cytotoxic CD8+ T Lymphocyte (CTL)
Our patented approach, using pre-defined T cell targets, allows virus infected cells, viral induced cancer cells, and several non-virally induced cancers to be directly targeted by Tevogen’s T cell products. Nature uses this approach to rid us of virus infections. Many cancer cells can be targeted and killed in the same way.
Technology to Bring Targets for Tevogen’s Allogeneic CD8+ Cytotoxic T Lymphocytes to Cancer Cells Being Marked for Elimination
In some cases, cancer cells may not express an ideal T cell target on their own. It is possible to bring a well-recognized target to the cancer cells using monoclonal antibodies or liposomes. This allows the Tevogen’s target specific cytotoxic T cells to then attack the cancer cells.
Unlike CAR-T or BITE antibody approaches which recruit a very heterogeneous group of T cells to the tumor, Tevogen’s approach instead focuses a highly purified population of killer T cells on the tumor, with far more potential to accomplish the task of eradicating the cancer.
 Abed El-Hakim El-Kadiry, Moutih Rafei, and Riam Shammaa, “Cell Therapy: Types, Regulation, and Clinical Benefits,” Frontiers in Medicine (November 2021), 5.
“At the end of the day, it’s not about analysis of expenses and profits, it’s about the wife that will lose her husband, it’s about the granddaughter that will lose her grandfather. It’s about you and me. It’s about stopping this carnage.”
– Ryan Saadi